Peeters Martine, Aghokeng Fobang Avelin, Delaporte Eric. (2010). Genetic diversity among human immunodeficiency virus-1 non-B subtypes in viral load and drug resistance assays. Clinical Microbiology and Infection, 16 (10), p. 1525-1531. ISSN 1198-743X.
Titre du document
Genetic diversity among human immunodeficiency virus-1 non-B subtypes in viral load and drug resistance assays
Peeters Martine, Aghokeng Fobang Avelin, Delaporte Eric
Source
Clinical Microbiology and Infection, 2010,
16 (10), p. 1525-1531 ISSN 1198-743X
The tremendous diversity of human immunodeficiency virus (HIV)-1 strains circulating worldwide has an important impact on almost all aspects of the management of this infection, from the identification of infected persons, through treatment efficacy and monitoring, and prevention strategies such as vaccine design. The areas where HIV-1 genetic diversity is highest are those where the majority of patients in need of treatment and biological monitoring live. With increased access to treatment in these areas, it is expected that the demand for monitoring tools such as viral load assays and resistance tests will also increase, and their reliability will be critical. Regular updates of these assays during the last two decades have aimed at improving their performances in different ways that include their reliability with different HIV-1 strains. We here review to what extent HIV-1 genetic diversity still limits or not the use of currently available viral load and resistance tests.
