Duchon Stéphane, Bonnet Julien, Marcombe Sébastien, Zaim M., Corbel Vincent. (2009). Pyrethrum : a mixture of natural pyrethrins has potential for malaria vector control. Journal of Medical Entomology, 46 (3), p. 516-522. ISSN 0022-2585.
Titre du document
Pyrethrum : a mixture of natural pyrethrins has potential for malaria vector control
Duchon Stéphane, Bonnet Julien, Marcombe Sébastien, Zaim M., Corbel Vincent
Source
Journal of Medical Entomology, 2009,
46 (3), p. 516-522 ISSN 0022-2585
Pyrethrum is a natural mixture of six insecticidal esters, recognized for low mammalian toxicity and limited persistence in the environment. In this study, World Health Organization standard bioassays were Used to evaluate the performance of pyrethrum against both susceptible and pyrethroid-resistant Anopheles gambiae s.s. vie results showed that the intrinsic activity of pyrethrum was similar to that of permethrin but lower than that of deltamethrin against susceptible mosquitoes, However, pyrethrum was less affected by the presence of the kdr mutation than synthetic pyrethroids (with lower resistance ratios) and showed good knock-down effect, repellency, and blood-feeding inhibition against the pyrethroid-resistant strain. In laboratory condition, mosquito nets treated with 500-1,000 mg/m(2) (pyrethrum) remained effective, i.e., >80% mortality and/or >95% K-D effect, for 9 mo. Conversely, the efficacy and residual activity of pyrethrum (Pynet 5% EC) on substrates Was not conclusive, especially concerning Mod, which is it porous subtrate (mortality <80% after 3 mo at 2g/m(2)) These finding suggested that pyrethrum may be a potential alternative candidate For the impregnation of mosquito nets and textiles in are-as where resistance to pyrethroids has become problematic.
