Garavito G., Rincon J., Arteaga L., Hata Y., Bourdy Geneviève, Gimenez A., Pinzon R., Deharo Eric. (2006). Antimalarial activity of some Colombian medicinal plants. Journal of Ethnopharmacology, 107 (3), p. 460-462. ISSN 0378-8741.
Titre du document
Antimalarial activity of some Colombian medicinal plants
Garavito G., Rincon J., Arteaga L., Hata Y., Bourdy Geneviève, Gimenez A., Pinzon R., Deharo Eric
Source
Journal of Ethnopharmacology, 2006,
107 (3), p. 460-462 ISSN 0378-8741
Antimalarial activity of 10 vegetal extracts (9 ethanolic extracts and 1 crude alkaloid extract), obtained from eight species traditionally used in Colombia to treat malaria symptoms, was evaluated in culture using Plasmodium falciparum chloroquine resistant (FcB2) strain and in vivo on rodent malaria Plasmodium berghei. The activity on ferriprotoporphyrin biomineralization inhibition test (FBIT) was also assessed. Against Plasmodium falciparum, eight extracts displayed good activity Abuta grandifolia (Mart.) Sandwith (Menispermaceae) leaves, Acacia farnesiana (L.) Willd. (Mimosaceae) leaves, Acnistus arborescens (L.) Schltdl. (Solanaceae) aerial part, Croton leptostachyus Knuth (Euphorbiaceae) aerial part, Piper cumanense Kunth (Piperaceae) fruits and leaves, Piper holtonii C. DC. (Piperaceae) aerial part and Xylopia aromatica (Lam.) Mart. (Annonaceae) bark with IC50 values ranging from < 1 to 2.1 mu g/ml, while in the in vivo model only Abuta grandifolia alkaloid crude extract exhibits activity, inhibiting 66% of the parasite growth at 250 mg/kg/day. In the FBIT model, five extracts were active (Abuta grandifolia, Croton leptostachyus, Piper cumanense fruit and leaves and Xylopia aromatica). (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde végétal [076]
