@article{fdi:010037646,
  title = {{A}ntimalarial activity of some {C}olombian medicinal plants},
  author = {{G}aravito, {G}. and {R}incon, {J}. and {A}rteaga, {L}. and {H}ata, {Y}. and {B}ourdy, {G}enevi{\`e}ve and {G}imenez, {A}. and {P}inzon, {R}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ntimalarial activity of 10 vegetal extracts (9 ethanolic extracts and 1 crude alkaloid extract), obtained from eight species traditionally used in {C}olombia to treat malaria symptoms, was evaluated in culture using {P}lasmodium falciparum chloroquine resistant ({F}c{B}2) strain and in vivo on rodent malaria {P}lasmodium berghei. {T}he activity on ferriprotoporphyrin biomineralization inhibition test ({FBIT}) was also assessed. {A}gainst {P}lasmodium falciparum, eight extracts displayed good activity {A}buta grandifolia ({M}art.) {S}andwith ({M}enispermaceae) leaves, {A}cacia farnesiana ({L}.) {W}illd. ({M}imosaceae) leaves, {A}cnistus arborescens ({L}.) {S}chltdl. ({S}olanaceae) aerial part, {C}roton leptostachyus {K}nuth ({E}uphorbiaceae) aerial part, {P}iper cumanense {K}unth ({P}iperaceae) fruits and leaves, {P}iper holtonii {C}. {DC}. ({P}iperaceae) aerial part and {X}ylopia aromatica ({L}am.) {M}art. ({A}nnonaceae) bark with {IC}50 values ranging from < 1 to 2.1 mu g/ml, while in the in vivo model only {A}buta grandifolia alkaloid crude extract exhibits activity, inhibiting 66% of the parasite growth at 250 mg/kg/day. {I}n the {FBIT} model, five extracts were active ({A}buta grandifolia, {C}roton leptostachyus, {P}iper cumanense fruit and leaves and {X}ylopia aromatica). (c) 2006 {E}lsevier {I}reland {L}td. {A}ll rights reserved.},
  keywords = {malaria ; antimalarials ; {C}olombia ; medicinal plants ; {P}lasmodium},
  booktitle = {},
  journal = {{J}ournal of {E}thnopharmacology},
  volume = {107},
  numero = {3},
  pages = {460--462},
  ISSN = {0378-8741},
  year = {2006},
  DOI = {10.1016/j.jep.2006.03.033},
  URL = {https://www.documentation.ird.fr/hor/fdi:010037646},
}