Liégeois Florian, Courgnaud Valérie, Switzer W.M., Murphy H.W., Loul S., Aghokeng Fobang Avelin, Pourrut Xavier, Mpoudi Ngolé E., Delaporte Eric, Peeters Martine. (2006). Molecular characterization of a novel simian immunodeficiency virus lineage (SIVtal) from northern talapoins (Miopithecus ogouensis). Virology, 349 (1), p. 55-65. ISSN 0042-6822.
Titre du document
Molecular characterization of a novel simian immunodeficiency virus lineage (SIVtal) from northern talapoins (Miopithecus ogouensis)
Année de publication
2006
Auteurs
Liégeois Florian, Courgnaud Valérie, Switzer W.M., Murphy H.W., Loul S., Aghokeng Fobang Avelin, Pourrut Xavier, Mpoudi Ngolé E., Delaporte Eric, Peeters Martine
Source
Virology, 2006,
349 (1), p. 55-65 ISSN 0042-6822
Simian immunodeficiency viruses (SIVs) are found in an extensive number of African primates, and humans continue to be exposed to these viruses by hunting and handling of primate bushmeat and following occupational exposures to captive nonhuman primates. Here, we report the molecular characterization of a new SIV lineage, SIVtal, from wild-caught and captive talapoin monkeys (Miopithecus ogouensis) from Cameroon and U.S. zoos, respectively. Phylogenetic tree analyses of a small fragment in the pol gene indicated that all SIVtaI strains clustered together forming a single species-specific lineage. Full-length sequence analysis for two strains, SIVtal-00CM266 and SlVtal-01CM8023, from wild-caught animals in Cameroon confirmed that SlVtal was distinct from all primate lentiviruses isolated so far and represents a new SIV lineage. Phylogenetic analyses in different viral genes showed a significant clustering of the SlVtal lineage with the Cercopithecus-specific SIVs. In addition, SlVtal and Cercopithecus-specific SIVs share functional motifs in Gag and Env that distinguish them from other primate lentiviruses. Like SIVsyk and SlVdeb, a vpu gene homologue was also absent in SIVtal. Although northern talapoins belong to the Miopithecus genus, their SIVs belong to the Cercopithecus SIV lineage, suggesting evolution from a common ancestor or cross-species transmission between both primate genera. (c) 2006 Elsevier Inc. All rights reserved.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010035662]
Identifiant IRD
fdi:010035662
