@article{fdi:010035662, title = {{M}olecular characterization of a novel simian immunodeficiency virus lineage ({SIV}tal) from northern talapoins ({M}iopithecus ogouensis)}, author = {{L}i{\'e}geois, {F}lorian and {C}ourgnaud, {V}al{\'e}rie and {S}witzer, {W}.{M}. and {M}urphy, {H}.{W}. and {L}oul, {S}. and {A}ghokeng {F}obang, {A}velin and {P}ourrut, {X}avier and {M}poudi {N}gol{\'e}, {E}. and {D}elaporte, {E}ric and {P}eeters, {M}artine}, editor = {}, language = {{ENG}}, abstract = {{S}imian immunodeficiency viruses ({SIV}s) are found in an extensive number of {A}frican primates, and humans continue to be exposed to these viruses by hunting and handling of primate bushmeat and following occupational exposures to captive nonhuman primates. {H}ere, we report the molecular characterization of a new {SIV} lineage, {SIV}tal, from wild-caught and captive talapoin monkeys ({M}iopithecus ogouensis) from {C}ameroon and {U}.{S}. zoos, respectively. {P}hylogenetic tree analyses of a small fragment in the pol gene indicated that all {SIV}ta{I} strains clustered together forming a single species-specific lineage. {F}ull-length sequence analysis for two strains, {SIV}tal-00{CM}266 and {S}l{V}tal-01{CM}8023, from wild-caught animals in {C}ameroon confirmed that {S}l{V}tal was distinct from all primate lentiviruses isolated so far and represents a new {SIV} lineage. {P}hylogenetic analyses in different viral genes showed a significant clustering of the {S}l{V}tal lineage with the {C}ercopithecus-specific {SIV}s. {I}n addition, {S}l{V}tal and {C}ercopithecus-specific {SIV}s share functional motifs in {G}ag and {E}nv that distinguish them from other primate lentiviruses. {L}ike {SIV}syk and {S}l{V}deb, a vpu gene homologue was also absent in {SIV}tal. {A}lthough northern talapoins belong to the {M}iopithecus genus, their {SIV}s belong to the {C}ercopithecus {SIV} lineage, suggesting evolution from a common ancestor or cross-species transmission between both primate genera. (c) 2006 {E}lsevier {I}nc. {A}ll rights reserved.}, keywords = {{SIV} ; non human primate ; talapoin ; {HIV} ; evolution ; {C}ameroon}, booktitle = {}, journal = {{V}irology}, volume = {349}, numero = {1}, pages = {55--65}, ISSN = {0042-6822}, year = {2006}, DOI = {10.1016/j.virol.2006.01.011}, URL = {https://www.documentation.ird.fr/hor/fdi:010035662}, }