Vidal Nicole, Mulanga Kabeya Claire, Nzilambi N., Delaporte Eric, Peeters Martine. (2000). Identification of a complex env subtype E HIV type 1 virus from the Democratic Republic of Congo, recombinant with A, G, H, J, K, and unknown subtypes. AIDS Research and Human Retroviruses, 16 (18), p. 2059-2064. ISSN 0889-2229.
Titre du document
Identification of a complex env subtype E HIV type 1 virus from the Democratic Republic of Congo, recombinant with A, G, H, J, K, and unknown subtypes
Année de publication
2000
Auteurs
Vidal Nicole, Mulanga Kabeya Claire, Nzilambi N., Delaporte Eric, Peeters Martine
Source
AIDS Research and Human Retroviruses, 2000,
16 (18), p. 2059-2064 ISSN 0889-2229
Up to now, all known env subtype E viruses (CRF01-AE) have had the same mosaic structure with subtype A, and no other env subtype E HIV-1 viruses with non-A subtypes in their genomes have been described. In this report, we describe the full-length genome sequence of an env subtype E isolate with a recombinant genome different from the prototype CRF01-AE strains. The 97CD-KTB-49 strain, obtained from a tuberculosis patient in Kinshasa, has a complex mosaic genome involving subtypes A, E, G, H, J, K, and several unknown fragments. The U sequences formed well-separated clusters together with previously described unknown fragments from CRF04-cpx (subtype I), and from Z321, the oldest intersubtype recombinant isolated in 1976 in the Democratic Republic of Congo. The complex recombinant virus from our study is not an isolated strain ; partial sequencing of a second strain, 97CD-KFE45, confirmed the breakpoints observed in the 97CD-KTB-49 strain in the regions sequenced. The complexity of these recombinant strains suggests a longstanding presence of subtype E in Central Africa. (Résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; VIRUS ; PHYLOGENIE ; ANALYSE GENETIQUE ; GENOME ; VIH 1 GROUPE E
Description Géographique
ZAIRE ; KINSHASA
Localisation
Fonds IRD [F B010025682] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010025682
