Weill M., Chandre Fabrice, Brengues Cécile, Manguin Sylvie, Akogbeto M., Pasteur N., Guillet Pierre, Raymond M. (2000). The kdr mutation occurs in the Mopti form of Anopheles gambiae s.s. through introgression. In :
Adaptation through introgression in An. gambiae. Insect Molecular Biology, 9 (5), p. 451-455. ISSN 0962-1075.
Titre du document
The kdr mutation occurs in the Mopti form of Anopheles gambiae s.s. through introgression
Année de publication
2000
Auteurs
Weill M., Chandre Fabrice, Brengues Cécile, Manguin Sylvie, Akogbeto M., Pasteur N., Guillet Pierre, Raymond M.
In
Adaptation through introgression in #An. gambiae$
Source
Insect Molecular Biology, 2000,
9 (5), p. 451-455 ISSN 0962-1075
Anopheles gambiae s.s. is a complex of sibling taxa characterized by various paracentric inversions. In west and central Africa, where several taxa are sympatric, a kdr mutation responsible for pyrethroid resistance has been described in only one (the S taxon), suggesting an absence of gene flow between them. Following a thorough sampling, we have found a kdr mutation in another taxon (M). To establish whether this mutation is the same event or not, the large intron upstream of the kdr mutation was sequenced to find polymorphic sites in suceptible/resistant and M/S mosquitoes. The low genetic diversity found in this DNA region indicates that a local genetic sweep has recently occured. However, some polymorphic sites were found, and it is therefore concluded that the kdr mutation in the M taxon is not an independent mutation event, and is best explained by an introgression from the S taxon. These results are discussed whithin the context of possible gene flow between members of An. gambiae s.s. taxa, and with the possible spread of the kdr mutation in other closely related malaria vectors of the An. gambiae complex. (Résumé d'auteur)
Plan de classement
Lutte [052ANOPAL04]
Descripteurs
PALUDISME ; MOUSTIQUE ; VECTEUR ; ANALYSE GENETIQUE ; TAXONOMIE ; POLYMORPHISME GENETIQUE ; INSECTICIDE CHIMIQUE ; SENSIBILITE RESISTANCE ; MUTATION ; REPARTITION GEOGRAPHIQUE ; ETUDE EXPERIMENTALE ; INTROGRESSION ; MUTATION KDR ; PYRETHROID
Description Géographique
AFRIQUE DE L'OUEST ; AFRIQUE CENTRALE ; BENIN ; CAMEROUN ; SENEGAL ; OUGANDA ; COTE D'IVOIRE ; BURKINA FASO ; CENTRAFRIQUE
Localisation
Fonds IRD [F B010024076] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010024076
