%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Weill, M.
%A Chandre, Fabrice
%A Brengues, Cécile
%A Manguin, Sylvie
%A Akogbeto, M.
%A Pasteur, N.
%A Guillet, Pierre
%A Raymond, M.
%T The kdr mutation occurs in the Mopti form of Anopheles gambiae s.s. through introgression
%B Adaptation through introgression in An. gambiae
%D 2000
%L fdi:010024076
%G ENG
%J Insect Molecular Biology
%@ 0962-1075
%K PALUDISME ; MOUSTIQUE ; VECTEUR ; ANALYSE GENETIQUE ; TAXONOMIE ; POLYMORPHISME GENETIQUE ; INSECTICIDE CHIMIQUE ; SENSIBILITE RESISTANCE ; MUTATION ; REPARTITION GEOGRAPHIQUE ; ETUDE EXPERIMENTALE
%K INTROGRESSION ; MUTATION KDR ; PYRETHROID
%K AFRIQUE DE L'OUEST ; AFRIQUE CENTRALE ; BENIN ; CAMEROUN ; SENEGAL ; OUGANDA ; COTE D'IVOIRE ; BURKINA FASO ; CENTRAFRIQUE
%N 5
%P 451-455
%R 10.1046/j.1365-2583.2000.00206.x
%U https://www.documentation.ird.fr/hor/fdi:010024076
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_57-58/010024076.pdf
%V 9
%W Horizon (IRD)
%X #Anopheles gambiae$ s.s. is a complex of sibling taxa characterized by various paracentric inversions. In west and central Africa, where several taxa are sympatric, a kdr mutation responsible for pyrethroid resistance has been described in only one (the S taxon), suggesting an absence of gene flow between them. Following a thorough sampling, we have found a kdr mutation in another taxon (M). To establish whether this mutation is the same event or not, the large intron upstream of the kdr mutation was sequenced to find polymorphic sites in suceptible/resistant and M/S mosquitoes. The low genetic diversity found in this DNA region indicates that a local genetic sweep has recently occured. However, some polymorphic sites were found, and it is therefore concluded that the kdr mutation in the M taxon is not an independent mutation event, and is best explained by an introgression from the S taxon. These results are discussed whithin the context of possible gene flow between members of #An. gambiae$ s.s. taxa, and with the possible spread of the kdr mutation in other closely related malaria vectors of the #An. gambiae$ complex. (Résumé d'auteur)
%$ 052ANOPAL04