Fournet Alain, Rojas de Arias A., Ferreira M.E., Nakayama H., Torres de Ortiz S., Schinini A., Samudio M., Vera de Bilbao N., Lavault M., Bonté F. (2000). Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model. International Journal of Antimicrobial Agents, 13, p. 189-195. ISSN 0924-8579.
Titre du document
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model
Année de publication
2000
Type de document
Article
Auteurs
Fournet Alain, Rojas de Arias A., Ferreira M.E., Nakayama H., Torres de Ortiz S., Schinini A., Samudio M., Vera de Bilbao N., Lavault M., Bonté F.
Source
International Journal of Antimicrobial Agents, 2000,
13, p. 189-195 ISSN 0924-8579
We have shown previously that daphnoline and cepharanthine are active against Trypanosoma cruzi and inhibited trypanothione reductase. The effects of oral treatments with daphnoline, cepharanthine and benznidazole were examined in Balb/c mice infected with T. cruzi acutely and chronically. In acute infections, parasitaemia was significantly reduced in the daphnoline-treated mice compared with controls and benznidazole-treated mice. The parasitological cure rate was increased in mice treated with daphnoline. Fifty days after infection, the negative serological response in both models was significantly different for the three tested drugs. Daphnoline showed the highest negative serological rate (48%). In chronically infected mice treated with daphnoline, we were unable to detect parasites in 70% of mice. The results obtained of oral treatment of daphnoline suggest that this bisbenzylisoquinoline may be useful in the treatment of acute and chronic Chagas' disease. This was not seen with cepharanthine, and excellent trypanothione reductase inhibitor. (Résumé d'auteur)
