@article{fdi:010020038,
  title = {{E}fficacy of the bisbenzylisoquinoline alkaloids in acute and chronic {T}rypanosoma cruzi murine model},
  author = {{F}ournet, {A}lain and {R}ojas de {A}rias, {A}. and {F}erreira, {M}.{E}. and {N}akayama, {H}. and {T}orres de {O}rtiz, {S}. and {S}chinini, {A}. and {S}amudio, {M}. and {V}era de {B}ilbao, {N}. and {L}avault, {M}. and {B}ont{\'e}, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e have shown previously that daphnoline and cepharanthine are active against #{T}rypanosoma cruzi$ and inhibited trypanothione reductase. {T}he effects of oral treatments with daphnoline, cepharanthine and benznidazole were examined in {B}alb/c mice infected with #{T}. cruzi$ acutely and chronically. {I}n acute infections, parasitaemia was significantly reduced in the daphnoline-treated mice compared with controls and benznidazole-treated mice. {T}he parasitological cure rate was increased in mice treated with daphnoline. {F}ifty days after infection, the negative serological response in both models was significantly different for the three tested drugs. {D}aphnoline showed the highest negative serological rate (48%). {I}n chronically infected mice treated with daphnoline, we were unable to detect parasites in 70% of mice. {T}he results obtained of oral treatment of daphnoline suggest that this bisbenzylisoquinoline may be useful in the treatment of acute and chronic {C}hagas' disease. {T}his was not seen with cepharanthine, and excellent trypanothione reductase inhibitor. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{MALADIE} {DE} {CHAGAS} ; {TRAITEMENT} {MEDICAL} ; {MEDICAMENT} ; {ALCALOIDE} ; {ACTIVITE} {BIOLOGIQUE} ; {ETUDE} {EXPERIMENTALE} ; {ETUDE} {COMPARATIVE} ; {CEPHARANTHINE} ; {DAPHNOLINE} ; {BENZNIDAZOLE}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {A}ntimicrobial {A}gents},
  volume = {13},
  numero = {},
  pages = {189--195},
  ISSN = {0924-8579},
  year = {2000},
  DOI = {10.1016/{S}0924-8579(99)00117-{X}},
  URL = {https://www.documentation.ird.fr/hor/fdi:010020038},
}