Publications des scientifiques de l'IRD

Bibollet-Ruche Frédéric, Loussert-Ajaka I., Simon F., Mboup S., Mpoudi Ngolé E., Saman E., Delaporte Eric, Peeters Martine. (1998). Genetic characterization of accessory genes from human immunodeficiency virus type 1 group 0 strains. AIDS Research and Human Retroviruses, 14 (11), p. 951-961. ISSN 0889-2229.

Titre du document
Genetic characterization of accessory genes from human immunodeficiency virus type 1 group 0 strains
Année de publication
1998
Type de document
Article
Auteurs
Bibollet-Ruche Frédéric, Loussert-Ajaka I., Simon F., Mboup S., Mpoudi Ngolé E., Saman E., Delaporte Eric, Peeters Martine
Source
AIDS Research and Human Retroviruses, 1998, 14 (11), p. 951-961 ISSN 0889-2229
Human immunodeficiency virus type 1 (HIV-1) group O strains have been described as highly divergent, compared with the vast majority of the viruses involved in the worldwide AIDS pandemic, classified in group M. To gain new insights into the diversity and genetic characteristics of group O, we have sequenced the accessory gene region (from vif to vpu) of 14 isolates. Analyses of the deduced amino acid sequences for Vil, Vpr, the first exon of Tat, and Vpu indicate that most of the functional domains of these proteins, as described for group M viruses, are highly conserved and retained among all the group O strains we have characterized. The only difference concerns the Vif phosphorylation sites, which are absent in all of the group O isolates we have sequenced ; in contrast, they are well conserved in nearly all of the group M isolates, in which they play critical roles in the regulation of viral replication and infectivity. As already observed for group M isolates, the Vpu protein is also highly diverse among group O strains. Phylogenetic analyses of these sequences indicate that HIV-1 group O can be separated into four different clusters, containing most of the strains we have characterized (except one, which clusters outside of the analyzed viruses). Taking into account the criteria used for clades in group M, we were not able to define group O clades definitively. (Résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; VIRUS ; SOUCHE ; DIVERSITE GENETIQUE ; TECHNIQUE PCR ; ACIDE AMINE ; PHYLOGENIE ; VIH-1 GROUPE O
Localisation
Fonds IRD [F B010014906]
Identifiant IRD
fdi:010014906
Contact