Publications des scientifiques de l'IRD

Garcia André, Cot Michel, Chippaux Jean-Philippe, Ranque S., Feingold J., Demenais F., Abel L. (1998). Genetic control of blood infection levels in human malaria : evidence for a complex genetic model. American Journal of Tropical Medicine and Hygiene, 58 (4), p. 480-488. ISSN 0002-9637.

Titre du document
Genetic control of blood infection levels in human malaria : evidence for a complex genetic model
Année de publication
1998
Type de document
Article
Auteurs
Garcia André, Cot Michel, Chippaux Jean-Philippe, Ranque S., Feingold J., Demenais F., Abel L.
Source
American Journal of Tropical Medicine and Hygiene, 1998, 58 (4), p. 480-488 ISSN 0002-9637
There is now accumulating evidence for the involvement of genetic factors in the control of immune response against malaria. These arguments come from numerous animal models, from population studies showing associations of red blood cell genetic defects as well as HLA antigens with severe malaria, and from familial studies including a recent segregation analysis, which led to detection of a major gene effect predisposing to high infection levels. The heterogeneity and complexity of this genetic control is one of the main findings of these previous studies, and probably a major cause of the difficulty in developping an effective malaria vaccine. A segregation analysis of blood infection levels is performed here in 44 pedigrees living in the tropical rain forest of southern Cameroon and exposed to high vectorial transmission intensity. The results confirm the existence of complex genetic factors controlling blood infection levels in human malaria but are not consistent with the parent-offspring transmission of a single Mendelian gene. This study also shows the dramatic effect of age on infection levels and its interaction with a putative major gene suggesting that genetic related differences are much more important in children than in adults. Further genetic studies focused on children may help to identify the nature of the genetic factors involved in the expression of human malaria, by means of linkage analyses using both familial information and genetic markers. (Résumé d'auteur)
Plan de classement
Epidémiologie du paludisme [052ANOPAL03]
Descripteurs
PALUDISME ; IMMUNOLOGIE ; ANALYSE STATISTIQUE ; SEGREGATION ; ETUDE COMPARATIVE ; EPIDEMIOLOGIE GENETIQUE
Description Géographique
CAMEROUN SUD
Localisation
Fonds IRD [F B010013700] ; Montpellier (Centre IRD)
Identifiant IRD
fdi:010013700
Contact