@article{fdi:010013700,
  title = {{G}enetic control of blood infection levels in human malaria : evidence for a complex genetic model},
  author = {{G}arcia, {A}ndr{\'e} and {C}ot, {M}ichel and {C}hippaux, {J}ean-{P}hilippe and {R}anque, {S}. and {F}eingold, {J}. and {D}emenais, {F}. and {A}bel, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}here is now accumulating evidence for the involvement of genetic factors in the control of immune response against malaria. {T}hese arguments come from numerous animal models, from population studies showing associations of red blood cell genetic defects as well as {HLA} antigens with severe malaria, and from familial studies including a recent segregation analysis, which led to detection of a major gene effect predisposing to high infection levels. {T}he heterogeneity and complexity of this genetic control is one of the main findings of these previous studies, and probably a major cause of the difficulty in developping an effective malaria vaccine. {A} segregation analysis of blood infection levels is performed here in 44 pedigrees living in the tropical rain forest of southern {C}ameroon and exposed to high vectorial transmission intensity. {T}he results confirm the existence of complex genetic factors controlling blood infection levels in human malaria but are not consistent with the parent-offspring transmission of a single {M}endelian gene. {T}his study also shows the dramatic effect of age on infection levels and its interaction with a putative major gene suggesting that genetic related differences are much more important in children than in adults. {F}urther genetic studies focused on children may help to identify the nature of the genetic factors involved in the expression of human malaria, by means of linkage analyses using both familial information and genetic markers. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {IMMUNOLOGIE} ; {ANALYSE} {STATISTIQUE} ; {SEGREGATION} ; {ETUDE} {COMPARATIVE} ; {EPIDEMIOLOGIE} {GENETIQUE} ; {CAMEROUN} {SUD}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {58},
  numero = {4},
  pages = {480--488},
  ISSN = {0002-9637},
  year = {1998},
  URL = {https://www.documentation.ird.fr/hor/fdi:010013700},
}