Publications des scientifiques de l'IRD

Peeters Martine, Koumaré B., Mulanga Claire, Brengues Cécile, Mounirou B., Bougoudogo F., Ravel Sophie, Bibollet-Ruche Frédéric, Delaporte Eric. (1998). Genetic subtypes of HIV type 1 and HIV type 2 strains in commercial sex workers from Bamako, Mali. AIDS Research and Human Retroviruses, 14 (1), p. 51-58. ISSN 0889-2229.

Titre du document
Genetic subtypes of HIV type 1 and HIV type 2 strains in commercial sex workers from Bamako, Mali
Année de publication
1998
Type de document
Article
Auteurs
Peeters Martine, Koumaré B., Mulanga Claire, Brengues Cécile, Mounirou B., Bougoudogo F., Ravel Sophie, Bibollet-Ruche Frédéric, Delaporte Eric
Source
AIDS Research and Human Retroviruses, 1998, 14 (1), p. 51-58 ISSN 0889-2229
In Africa the highest HIV infection rate has been reported among female commercial sex workers (CSWs) who are at increasing risk of acquiring and transmitting HIV infection. In October 1995, 176 CSWs were studied in Bamako, the capital city of Mali. The ages of the CSWs ranged from 15 to 50 years old (mean, 28.8 years). Only 20.45% of the 176 CSWs were Malian ; the majority were from Nigeria (32.9%) and Ghana (31.8%), and the remaining were from other African countries. Forty-one percent were active for less than 1 year as a commercial sex worker, and the length of prostitution for the remaining women ranged from 1 to 15 years (mean, 2.76). A total of 81 (46.02%) of the 176 CSWs were positive for HIV antibodies ; 63 (35.8%) were HIV-1 positive, 3.9% were HIV-2 posivitive, 11 (6.2%) had antibodies to HIV-1 and HIV-2, and none of them had antibodies to group O viruses. For all HIV antibody-positive samples, PBMCs were separated and genetic subtypes of HIV-1 were determined using the heteroduplex mobility assay (HMA), with ED5-ED12 as outer and ES7-ES8 as inner primers. Among the 66 HIV-1 strains characterized, 53 (80.3%) were subtype A, 2 (3.1%) belonged to subtype C, 1 (1.5%) belonged to subtype D, and 10 (15.1%) were identified as subtype G. Among the 10 subtype G strains, 8 were obtained from women who were very recent CSWs, with an activity of 1 year or less, assuming that there is a high probability that these infections occurred recently. Genetic subtypes of five HIV-2 viruses were determined by sequencing of the env and/or gag genes followed by phylogenetic analysis, and all of them belonged to subtype A. Comparison of HIV-1 and HIV-2 seroprevalence data from our study with previous data from Mali shows a significant rise in HIV-1 prevalence and a significant decrease in HIV-2 prevalence and confirms similar trends observed in neighboring countries... (D'après résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; PROSTITUTION ; VIRUS ; VARIABILITE GENETIQUE ; ANALYSE ; VIH-1 ; VIH-2 ; SEROPREVALENCE
Description Géographique
MALI ; BAMAKO
Localisation
Fonds IRD [F B010013501] ; Montpellier (Centre IRD)
Identifiant IRD
fdi:010013501
Contact