Penchenier Laurent, Mathieu-Daudé F., Brengues Cécile, Banuls Anne-Laure, Tibayrenc Michel. (1997). Population structure of Trypanosoma brucei S.L. in Cote d'Ivoire assayed by multilocus enzyme electrophoresis : epidemiological and taxonomical considerations. Journal of Parasitology, 83 (1), p. 19-22. ISSN 0022-3395.
Titre du document
Population structure of Trypanosoma brucei S.L. in Cote d'Ivoire assayed by multilocus enzyme electrophoresis : epidemiological and taxonomical considerations
Année de publication
1997
Type de document
Article
Auteurs
Penchenier Laurent, Mathieu-Daudé F., Brengues Cécile, Banuls Anne-Laure, Tibayrenc Michel
Source
Journal of Parasitology, 1997,
83 (1), p. 19-22 ISSN 0022-3395
Fifty-two Trypanosoma brucei stocks isolated in Côte d'Ivoire from sympatric locations were analyzed by cellulose acetate electrophoresis of isoenzymes. Of 13 genetic loci surveyed, 5 appeared as variable, which made it possible to delimit 12 different zymodemes. The most abundant zymodeme involved stocks isolated from both humans and pigs, which is consistent with the hypothesis that pig is a reservoir of human African trypanosomiasis in Côte d'Ivoire, as already proposed by other authors. Population genetic analysis of the isozyme data indicated a strong linkage disequilibrium, which suggests that genetic recombination is severely restricted in this sample and favors the hypothesis that the trypanosome populations surveyed are basically clonal. Nevertheless, additional studies are required to better estimate the long-term stability of these clones and the possible interference of gene exchange at an evolutionary scale. The results corroborate the hypothesis that a majority of human T. brucei stocks from West Africa correspond to a fairly homogeneous cluster of genotypes. (Résumé d'auteur)
Plan de classement
Epidémiologie des trypanosomiases [052GLOTRY02]
Descripteurs
MALADIE DU SOMMEIL ; AGENT PATHOGENE ; GENETIQUE DE POPULATION ; SPECIATION ; GENOTYPE ; ELECTROPHORESE ENZYMATIQUE
