Mazars E., Guyot K., Durand I., Dei-Cas E., Boucher S., Ben Abderrazak S., Banuls Anne-Laure, Tibayrenc Michel, Camus D. (1997). Isoenzyme diversity in Pneumocystis carinii from rats, mice, and rabbits. Journal of Infectious Diseases, 175 (3), p. 655-660. ISSN 0022-1899.
Titre du document
Isoenzyme diversity in Pneumocystis carinii from rats, mice, and rabbits
Année de publication
1997
Auteurs
Mazars E., Guyot K., Durand I., Dei-Cas E., Boucher S., Ben Abderrazak S., Banuls Anne-Laure, Tibayrenc Michel, Camus D.
Source
Journal of Infectious Diseases, 1997,
175 (3), p. 655-660 ISSN 0022-1899
Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised patients. To investigate the genetic diversity of P. carinii populations, multilocus enzyme electrophoresis was used to analyze five enzyme systems (malate dehydrogenase, glucose phosphate isomerase, leucine aminopeptidase, malic enzyme, and 6-phosphogluconate dehydrogenase). Only five different multilocus associations (zymodemes) were recorded for the 70 isolates studied. While only one multilocus combination was found in mice and rabbits, three different multilocus associations were recorded in rats. Population genetic tests and phylogenetic analysis strongly suggest that P. carinii genotypes are host-specific, in agreement with molecular study results, and that no genetic exchange occurs between genotypes from different host species. This hypothesis could be verified only by the evolutionary genetic approach, which relies here on multilocus analysis. (Résumé d'auteur)
Plan de classement
Divers [052MALTRA05]
Descripteurs
SIDA ; MALADIES ASSOCIEES ; BACTERIOSE ; AGENT PATHOGENE ; POLYMORPHISME ENZYMATIQUE ; ISOENZYME ; POLYMORPHISME GENETIQUE ; GENETIQUE DE POPULATION ; GENOTYPE ; EXPERIMENTATION ANIMALE ; PNEUMONIE
Localisation
Fonds IRD [F B010009122]
Identifiant IRD
fdi:010009122
