@article{fdi:010009122,
  title = {{I}soenzyme diversity in {P}neumocystis carinii from rats, mice, and rabbits},
  author = {{M}azars, {E}. and {G}uyot, {K}. and {D}urand, {I}. and {D}ei-{C}as, {E}. and {B}oucher, {S}. and {B}en {A}bderrazak, {S}. and {B}anuls, {A}nne-{L}aure and {T}ibayrenc, {M}ichel and {C}amus, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {#{P}neumocystis carinii$ is an opportunistic pathogen that causes pneumonia in immunocompromised patients. {T}o investigate the genetic diversity of #{P}. carinii$ populations, multilocus enzyme electrophoresis was used to analyze five enzyme systems (malate dehydrogenase, glucose phosphate isomerase, leucine aminopeptidase, malic enzyme, and 6-phosphogluconate dehydrogenase). {O}nly five different multilocus associations (zymodemes) were recorded for the 70 isolates studied. {W}hile only one multilocus combination was found in mice and rabbits, three different multilocus associations were recorded in rats. {P}opulation genetic tests and phylogenetic analysis strongly suggest that #{P}. carinii$ genotypes are host-specific, in agreement with molecular study results, and that no genetic exchange occurs between genotypes from different host species. {T}his hypothesis could be verified only by the evolutionary genetic approach, which relies here on multilocus analysis. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{SIDA} ; {MALADIES} {ASSOCIEES} ; {BACTERIOSE} ; {AGENT} {PATHOGENE} ; {POLYMORPHISME} {ENZYMATIQUE} ; {ISOENZYME} ; {POLYMORPHISME} {GENETIQUE} ; {GENETIQUE} {DE} {POPULATION} ; {GENOTYPE} ; {EXPERIMENTATION} {ANIMALE} ; {PNEUMONIE}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {175},
  numero = {3},
  pages = {655--660},
  ISSN = {0022-1899},
  year = {1997},
  URL = {https://www.documentation.ird.fr/hor/fdi:010009122},
}