Vasiliu A., Martinez L., Gupta R. K., Hamada Y., Ness T., Kay A., Bonnet Maryline, Sester M., Kaufmann S. H. E., Lange C., Mandalakas A. M. (2024). Tuberculosis prevention : current strategies and future directions. Clinical Microbiology and Infection, 30 (9), p. 1123-1130. ISSN 1198-743X.
Titre du document
Tuberculosis prevention : current strategies and future directions
Vasiliu A., Martinez L., Gupta R. K., Hamada Y., Ness T., Kay A., Bonnet Maryline, Sester M., Kaufmann S. H. E., Lange C., Mandalakas A. M.
Source
Clinical Microbiology and Infection, 2024,
30 (9), p. 1123-1130 ISSN 1198-743X
Background: An estimated one fourth of the world's population is infected with Mycobacterium tuberculosis, and 5-10% of those infected develop tuberculosis in their lifetime. Preventing tuberculosis is one of the most underutilized but essential components of curtailing the tuberculosis epidemic. Moreover, current evidence illustrates that tuberculosis manifestations occur along a dynamic spectrum from infection to disease rather than a binary state as historically conceptualized. Elucidating determinants of transition between these states is crucial to decreasing the tuberculosis burden and reaching the END-TB Strategy goals as defined by the WHO. Vaccination, detection of infection, and provision of preventive treatment are key elements of tuberculosis prevention. Objectives: This review provides a comprehensive summary of recent evidence and state-of-the-art updates on advancements to prevent tuberculosis in various settings and high-risk populations. Sources: We identified relevant studies in the literature and synthesized the findings to provide an overview of the current state of tuberculosis prevention strategies and latest research developments. Content: We present the current knowledge and recommendations regarding tuberculosis prevention, with a focus on M. bovis Bacille-Calmette-Guerin vaccination and novel vaccine candidates, tests for latent infection with M. tuberculosis, regimens available for tuberculosis preventive treatment and recommendations in low- and high-burden settings.
