@article{PAR00028195,
  title = {{T}uberculosis prevention : current strategies and future directions},
  author = {{V}asiliu, {A}. and {M}artinez, {L}. and {G}upta, {R}. {K}. and {H}amada, {Y}. and {N}ess, {T}. and {K}ay, {A}. and {B}onnet, {M}aryline and {S}ester, {M}. and {K}aufmann, {S}. {H}. {E}. and {L}ange, {C}. and {M}andalakas, {A}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}n estimated one fourth of the world's population is infected with {M}ycobacterium tuberculosis, and 5-10% of those infected develop tuberculosis in their lifetime. {P}reventing tuberculosis is one of the most underutilized but essential components of curtailing the tuberculosis epidemic. {M}oreover, current evidence illustrates that tuberculosis manifestations occur along a dynamic spectrum from infection to disease rather than a binary state as historically conceptualized. {E}lucidating determinants of transition between these states is crucial to decreasing the tuberculosis burden and reaching the {END}-{TB} {S}trategy goals as defined by the {WHO}. {V}accination, detection of infection, and provision of preventive treatment are key elements of tuberculosis prevention. {O}bjectives: {T}his review provides a comprehensive summary of recent evidence and state-of-the-art updates on advancements to prevent tuberculosis in various settings and high-risk populations. {S}ources: {W}e identified relevant studies in the literature and synthesized the findings to provide an overview of the current state of tuberculosis prevention strategies and latest research developments. {C}ontent: {W}e present the current knowledge and recommendations regarding tuberculosis prevention, with a focus on {M}. bovis {B}acille-{C}almette-{G}uerin vaccination and novel vaccine candidates, tests for latent infection with {M}. tuberculosis, regimens available for tuberculosis preventive treatment and recommendations in low- and high-burden settings.},
  keywords = {{BCG} ; {IGRA} ; {LTBI} ; {N}ovel vaccine candidates ; {P}reventive treatment ; {TB} ; spectrum ; {TPT} ; {TST} ; {T}uberculosis control},
  booktitle = {},
  journal = {{C}linical {M}icrobiology and {I}nfection},
  volume = {30},
  numero = {9},
  pages = {1123--1130},
  ISSN = {1198-743{X}},
  year = {2024},
  DOI = {10.1016/j.cmi.2023.10.023},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00028195},
}