Boyer M., Yutin N., Pagnier I., Barrassi L., Fournous G., Espinosa L., Robert C., Azza S., Sun S. Y., Rossmann M. G., Suzan-Monti M., La Scola B., Koonin E. V., Raoult Didier. (2009). Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms. Proceedings of the National Academy of Sciences of the United States of America, 106 (51), p. 21848-21853. ISSN 0027-8424.
Titre du document
Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms
Année de publication
2009
Auteurs
Boyer M., Yutin N., Pagnier I., Barrassi L., Fournous G., Espinosa L., Robert C., Azza S., Sun S. Y., Rossmann M. G., Suzan-Monti M., La Scola B., Koonin E. V., Raoult Didier
Source
Proceedings of the National Academy of Sciences of the United States of America, 2009,
106 (51), p. 21848-21853 ISSN 0027-8424
Giant viruses such as Mimivirus isolated from amoeba found in aquatic habitats show biological sophistication comparable to that of simple cellular life forms and seem to evolve by similar mechanisms, including extensive gene duplication and horizontal gene transfer (HGT), possibly in part through a viral parasite, the virophage. We report here the isolation of "Marseille' virus, a previously uncharacterized giant virus of amoeba. The virions of Marseillevirus encompass a 368-kb genome, a minimum of 49 proteins, and some messenger RNAs. Phylogenetic analysis of core genes indicates that Marseillevirus is the prototype of a family of nucleocytoplasmic large DNA viruses (NCLDV) of eukaryotes. The genome repertoire of the virus is composed of typical NCLDV core genes and genes apparently obtained from eukaryotic hosts and their parasites or symbionts, both bacterial and viral. We propose that amoebae are "melting pots' of microbial evolution where diverse forms emerge, including giant viruses with complex gene repertoires of various origins.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010048512]
Identifiant IRD
PAR00004561
