Publications des scientifiques de l'IRD

Tuikue Ndam Nicaise, Salanti A., Le Hesran Jean-Yves, Cottrell Gilles, Fievet Nadine, Turner L., Sow S., Dangou J.M., Theander T., Deloron Philippe. (2006). Dynamics of Anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women. Journal of Infectious Diseases, 193 (5), p. 713-720.

Titre du document
Dynamics of Anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women
Année de publication
2006
Type de document
Article référencé dans le Web of Science WOS:000235535500014
Auteurs
Tuikue Ndam Nicaise, Salanti A., Le Hesran Jean-Yves, Cottrell Gilles, Fievet Nadine, Turner L., Sow S., Dangou J.M., Theander T., Deloron Philippe
Source
Journal of Infectious Diseases, 2006, 193 (5), p. 713-720
Background. Pregnancy-associated malaria (PAM) is precipitated by the accumulation of parasites in the placental intervillous spaces and causes maternal anemia and low birth weight. In PAM, placental parasites adhere to chondroitin sulfate A (CSA) through a unique set of variant surface antigens (VSA(PAM)). Several studies have shown that 1 var gene, var2csa, is transcribed at high levels and expressed in CSA-binding Plasmodium falciparum parasites. Methods. Plasma levels of anti-VAR2CSA immunoglobulin G (IgG) in Senegalese women were measured during pregnancy by enzyme-linked immunosorbent assay, using 3 recombinant proteins representing 3 domains of the var2csa gene product. Results. The 3 recombinant proteins were specifically recognized by plasma from pregnant women but not by control plasma. A parity-dependent recognition pattern was observed with 2 of the 3 VAR2CSA antigens. A kinetic study demonstrated that a single P. falciparum infection was able to trigger a VAR2CSA-specific antibody response. Among women with infected placentas, women with high anti-VAR2CSA IgG levels at enrollment were more likely to present with a past infection than with an acute/chronic infection. Conclusions. Anti-VAR2CSA IgGs are involved in clinical protection against pregnancy-associated malaria and strengthens the hope for making a VAR2CSA- based vaccine.
Plan de classement
Santé : généralités [050]
Description Géographique
SENEGAL
Localisation
Fonds IRD
Identifiant IRD
PAR00000809
Contact