@article{PAR00000809,
  title = {{D}ynamics of {A}nti-{VAR}2{CSA} immunoglobulin {G} response in a cohort of senegalese pregnant women},
  author = {{T}uikue {N}dam, {N}icaise and {S}alanti, {A}. and {L}e {H}esran, {J}ean-{Y}ves and {C}ottrell, {G}illes and {F}ievet, {N}adine and {T}urner, {L}. and {S}ow, {S}. and {D}angou, {J}.{M}. and {T}heander, {T}. and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {P}regnancy-associated malaria ({PAM}) is precipitated by the accumulation of parasites in the placental intervillous spaces and causes maternal anemia and low birth weight. {I}n {PAM}, placental parasites adhere to chondroitin sulfate {A} ({CSA}) through a unique set of variant surface antigens ({VSA}({PAM})). {S}everal studies have shown that 1 var gene, var2csa, is transcribed at high levels and expressed in {CSA}-binding {P}lasmodium falciparum parasites. {M}ethods. {P}lasma levels of anti-{VAR}2{CSA} immunoglobulin {G} ({I}g{G}) in {S}enegalese women were measured during pregnancy by enzyme-linked immunosorbent assay, using 3 recombinant proteins representing 3 domains of the var2csa gene product. {R}esults. {T}he 3 recombinant proteins were specifically recognized by plasma from pregnant women but not by control plasma. {A} parity-dependent recognition pattern was observed with 2 of the 3 {VAR}2{CSA} antigens. {A} kinetic study demonstrated that a single {P}. falciparum infection was able to trigger a {VAR}2{CSA}-specific antibody response. {A}mong women with infected placentas, women with high anti-{VAR}2{CSA} {I}g{G} levels at enrollment were more likely to present with a past infection than with an acute/chronic infection. {C}onclusions. {A}nti-{VAR}2{CSA} {I}g{G}s are involved in clinical protection against pregnancy-associated malaria and strengthens the hope for making a {VAR}2{CSA}- based vaccine.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {193},
  numero = {5},
  pages = {713--720},
  year = {2006},
  DOI = {10.1086/500146},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000809},
}