Hocquemiller R., Cortes D., Arango G.J., Myint S.H., Cavé A., Angelo A., Munoz V., Fournet Alain. (1991). Isolement et synthèse de l'espintanol, nouveau monoterpène antiparasitaire. Journal of Natural Products, 54 (2), p. 445-452. ISSN 0163-3864.
Titre du document
Isolement et synthèse de l'espintanol, nouveau monoterpène antiparasitaire
Année de publication
1991
Type de document
Article
Auteurs
Hocquemiller R., Cortes D., Arango G.J., Myint S.H., Cavé A., Angelo A., Munoz V., Fournet Alain
Source
Journal of Natural Products, 1991,
54 (2), p. 445-452 ISSN 0163-3864
The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel : espintanol (3a), responsible for the antiparasite activity, and O-methylespintanol (4). Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol. (Résumé d'auteur)
