%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Hocquemiller, R.
%A Cortes, D.
%A Arango, G.J.
%A Myint, S.H.
%A Cavé, A.
%A Angelo, A.
%A Munoz, V.
%A Fournet, Alain
%T Isolement et synthèse de l'espintanol, nouveau monoterpène antiparasitaire
%D 1991
%L fdi:34102
%G FRE
%J Journal of Natural Products
%@ 0163-3864
%K MALADIE DE CHAGAS ; LEISHMANIOSE ; ETUDE COMPARATIVE ; ACTIVITE BIOLOGIQUE ; EXPERIMENTATION IN VITRO ; SUBSTANCE NATURELLE
%K MONOTERPENE ; ESPINTANOL ; PROMASTIGOTE ; AMASTIGOTE ; SOUCHE TYPIFIEE
%K BOLIVIE
%N 2
%P 445-452
%R 10.1021/np50074a015
%U https://www.documentation.ird.fr/hor/fdi:34102
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_5/b_fdi_31-32/34102.pdf
%V 54
%W Horizon (IRD)
%X The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of #Oxandra espintana$ have been investigated. Four aromatic monoterpenes were isolated, of which two are novel : espintanol (3a), responsible for the antiparasite activity, and O-methylespintanol (4). Espintanol was tested in vitro on 20 strains of #Trypanosoma cruzi$ and 12 strains of #Leishmania$ spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol. (Résumé d'auteur)
%$ 052GLOTRY03 ; 052PHLEIS03