Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas Sandra, Stigliani J. L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C. (2021). Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones. Journal of the American Chemical Society, 143 (10), p. 3697-3702. ISSN 0002-7863.
Titre du document
Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones
Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas Sandra, Stigliani J. L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C.
Source
Journal of the American Chemical Society, 2021,
143 (10), p. 3697-3702 ISSN 0002-7863
Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(alpha-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
