%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Salas-Ambrosio, P.
%A Tronnet, A.
%A Since, M.
%A Bourgeade-Delmas, Sandra
%A Stigliani, J. L.
%A Vax, A.
%A Lecommandoux, S.
%A Dupuy, B.
%A Verhaeghe, P.
%A Bonduelle, C.
%T Cyclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization : simple access to bioactive backbones
%D 2021
%L fdi:010081087
%G ENG
%J Journal of the American Chemical Society
%@ 0002-7863
%M ISI:000630322300007
%N 10
%P 3697-3702
%R 10.1021/jacs.0c13231
%U https://www.documentation.ird.fr/hor/fdi:010081087
%> https://www.documentation.ird.fr/intranet/publi/2021/03/010081087.pdf
%V 143
%W Horizon (IRD)
%X Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(alpha-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections.
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