@article{fdi:010081087, title = {{C}yclic poly(alpha-peptoid)s by lithium bis(trimethylsilyl)amide ({L}i{HMDS})-mediated ring-expansion polymerization : simple access to bioactive backbones}, author = {{S}alas-{A}mbrosio, {P}. and {T}ronnet, {A}. and {S}ince, {M}. and {B}ourgeade-{D}elmas, {S}andra and {S}tigliani, {J}. {L}. and {V}ax, {A}. and {L}ecommandoux, {S}. and {D}upuy, {B}. and {V}erhaeghe, {P}. and {B}onduelle, {C}.}, editor = {}, language = {{ENG}}, abstract = {{C}yclic polymers display unique physicochemical and biological properties. {H}owever, their development is often limited by their challenging preparation. {I}n this work, we present a simple route to cyclic poly(alpha-peptoids) from {N}-alkylated-{N}-carboxyanhydrides ({NNCA}) using {L}i{HMDS} promoted ring-expansion polymerization ({REP}) in {DMF}. {T}his new method allows the unprecedented use of lysine-like monomers in {REP} to design bioactive macrocycles bearing pharmaceutical potential against {C}lostridioides difficile, a bacterium responsible for nosocomial infections.}, keywords = {}, booktitle = {}, journal = {{J}ournal of the {A}merican {C}hemical {S}ociety}, volume = {143}, numero = {10}, pages = {3697--3702}, ISSN = {0002-7863}, year = {2021}, DOI = {10.1021/jacs.0c13231}, URL = {https://www.documentation.ird.fr/hor/fdi:010081087}, }