Toure O. A., Landry T. N., Assi S. B., Kone A. A., Gbessi E. A., Ako B. A., Coulibaly B., Kone B., Ouattara O., Beourou S., Koffi A., Remoué Franck, Rogier C. (2018). Malaria parasite clearance from patients following artemisinin-based combination therapy in Cote d'Ivoire. Infection and Drug Resistance, 11, p. 2031-2038. ISSN 1178-6973.
Titre du document
Malaria parasite clearance from patients following artemisinin-based combination therapy in Cote d'Ivoire
Année de publication
2018
Auteurs
Toure O. A., Landry T. N., Assi S. B., Kone A. A., Gbessi E. A., Ako B. A., Coulibaly B., Kone B., Ouattara O., Beourou S., Koffi A., Remoué Franck, Rogier C.
Source
Infection and Drug Resistance, 2018,
11, p. 2031-2038 ISSN 1178-6973
Introduction: Parasite clearance is useful to detect artemisinin resistance. The aim o f this study was to investigate parasite clearance in patients treated with artesunate + amodiaquine (AS + AQ) and artemether + lumefantrine (AL): the two artemisinin-based combination therapies (ACTs) recommended in the first-line treatment of uncomplicated malaria in Cote d'Ivoire. Methods: This study was conducted in Bouake, Cote d'Ivoire, from April to June 2016. Patients aged at least 6 months with uncomplicated malaria and treated with AS + AQ or AL were hospitalized for 3 days, and follow-up assessments were performed on days 3, 7, 14, 21, 28, 35, and 42. Blood smears were collected at the time of screening, pre-dose, and 6-hour intervals following the first dose of administration until two consecutive negative smears were recorded, thereafter at day 3 and follow-up visits. Parasite clearance was determined using the Worldwide Antimalarial Resistance Network's parasite clearance estimator. The primary end points were parasite clearance rate and time. Results: A total of 120 patients (57 in the AS + AQ group and 63 in the AL group) were randomized among 298 patients screened. The median parasite clearance time was 30 hours (IQR, 24-36 hours), for each ACT The median parasite clearance rate had a slope half-life of 2.36 hours (IQR, 1.85-2.88 hours) and 2.23 hours (IQR, 1.74-2.63 hours) for AS + AQ and A L, respectively. The polymerase chain reaction-corrected adequate clinical and parasitological response was 100% and 98.07% at day 42 for AS + AQ and AL, respectively. Conclusion: Patients treated with AS + AQ and AL had cleared parasites rapidly. ACTs are still efficacious in Bouake, Cote d'Ivoire, but continued efficacy monitoring of ACTs is needed.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde végétal [076]
Description Géographique
COTE D'IVOIRE ; BOUAKE
Localisation
Fonds IRD [F B010074357]
Identifiant IRD
fdi:010074357
