@article{fdi:010074357,
  title = {{M}alaria parasite clearance from patients following artemisinin-based combination therapy in {C}ote d'{I}voire},
  author = {{T}oure, {O}. {A}. and {L}andry, {T}. {N}. and {A}ssi, {S}. {B}. and {K}one, {A}. {A}. and {G}bessi, {E}. {A}. and {A}ko, {B}. {A}. and {C}oulibaly, {B}. and {K}one, {B}. and {O}uattara, {O}. and {B}eourou, {S}. and {K}offi, {A}. and {R}emou{\'e}, {F}ranck and {R}ogier, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction: {P}arasite clearance is useful to detect artemisinin resistance. {T}he aim o f this study was to investigate parasite clearance in patients treated with artesunate + amodiaquine ({AS} + {AQ}) and artemether + lumefantrine ({AL}): the two artemisinin-based combination therapies ({ACT}s) recommended in the first-line treatment of uncomplicated malaria in {C}ote d'{I}voire. {M}ethods: {T}his study was conducted in {B}ouake, {C}ote d'{I}voire, from {A}pril to {J}une 2016. {P}atients aged at least 6 months with uncomplicated malaria and treated with {AS} + {AQ} or {AL} were hospitalized for 3 days, and follow-up assessments were performed on days 3, 7, 14, 21, 28, 35, and 42. {B}lood smears were collected at the time of screening, pre-dose, and 6-hour intervals following the first dose of administration until two consecutive negative smears were recorded, thereafter at day 3 and follow-up visits. {P}arasite clearance was determined using the {W}orldwide {A}ntimalarial {R}esistance {N}etwork's parasite clearance estimator. {T}he primary end points were parasite clearance rate and time. {R}esults: {A} total of 120 patients (57 in the {AS} + {AQ} group and 63 in the {AL} group) were randomized among 298 patients screened. {T}he median parasite clearance time was 30 hours ({IQR}, 24-36 hours), for each {ACT} {T}he median parasite clearance rate had a slope half-life of 2.36 hours ({IQR}, 1.85-2.88 hours) and 2.23 hours ({IQR}, 1.74-2.63 hours) for {AS} + {AQ} and {A} {L}, respectively. {T}he polymerase chain reaction-corrected adequate clinical and parasitological response was 100% and 98.07% at day 42 for {AS} + {AQ} and {AL}, respectively. {C}onclusion: {P}atients treated with {AS} + {AQ} and {AL} had cleared parasites rapidly. {ACT}s are still efficacious in {B}ouake, {C}ote d'{I}voire, but continued efficacy monitoring of {ACT}s is needed.},
  keywords = {{P}lasmodium falciparum ; {ACT}s ; parasite clearance ; {C}ote d'{I}voire ; {COTE} {D}'{IVOIRE} ; {BOUAKE}},
  booktitle = {},
  journal = {{I}nfection and {D}rug {R}esistance},
  volume = {11},
  numero = {},
  pages = {2031--2038},
  ISSN = {1178-6973},
  year = {2018},
  DOI = {10.2147/idr.s167518},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074357},
}