%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Toure, O. A.
%A Landry, T. N.
%A Assi, S. B.
%A Kone, A. A.
%A Gbessi, E. A.
%A Ako, B. A.
%A Coulibaly, B.
%A Kone, B.
%A Ouattara, O.
%A Beourou, S.
%A Koffi, A.
%A Remoué, Franck
%A Rogier, C.
%T Malaria parasite clearance from patients following artemisinin-based combination therapy in Cote d'Ivoire
%D 2018
%L fdi:010074357
%G ENG
%J Infection and Drug Resistance
%@ 1178-6973
%K Plasmodium falciparum ; ACTs ; parasite clearance ; Cote d'Ivoire
%K COTE D'IVOIRE ; BOUAKE
%M ISI:000448612400003
%P 2031-2038
%R 10.2147/idr.s167518
%U https://www.documentation.ird.fr/hor/fdi:010074357
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-11/010074357.pdf
%V 11
%W Horizon (IRD)
%X Introduction: Parasite clearance is useful to detect artemisinin resistance. The aim o f this study was to investigate parasite clearance in patients treated with artesunate + amodiaquine (AS + AQ) and artemether + lumefantrine (AL): the two artemisinin-based combination therapies (ACTs) recommended in the first-line treatment of uncomplicated malaria in Cote d'Ivoire. Methods: This study was conducted in Bouake, Cote d'Ivoire, from April to June 2016. Patients aged at least 6 months with uncomplicated malaria and treated with AS + AQ or AL were hospitalized for 3 days, and follow-up assessments were performed on days 3, 7, 14, 21, 28, 35, and 42. Blood smears were collected at the time of screening, pre-dose, and 6-hour intervals following the first dose of administration until two consecutive negative smears were recorded, thereafter at day 3 and follow-up visits. Parasite clearance was determined using the Worldwide Antimalarial Resistance Network's parasite clearance estimator. The primary end points were parasite clearance rate and time. Results: A total of 120 patients (57 in the AS + AQ group and 63 in the AL group) were randomized among 298 patients screened. The median parasite clearance time was 30 hours (IQR, 24-36 hours), for each ACT The median parasite clearance rate had a slope half-life of 2.36 hours (IQR, 1.85-2.88 hours) and 2.23 hours (IQR, 1.74-2.63 hours) for AS + AQ and A L, respectively. The polymerase chain reaction-corrected adequate clinical and parasitological response was 100% and 98.07% at day 42 for AS + AQ and AL, respectively. Conclusion: Patients treated with AS + AQ and AL had cleared parasites rapidly. ACTs are still efficacious in Bouake, Cote d'Ivoire, but continued efficacy monitoring of ACTs is needed.
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