El-Demerdash A., Moriou C., Martin M. T., Petek Sylvain, Debitus Cécile, Al-Mourabit A. (2018). Unguiculins A-C : cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.. Natural Product Research, 32 (13), p. 1512-1517. ISSN 1478-6419.
Titre du document
Unguiculins A-C : cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.
El-Demerdash A., Moriou C., Martin M. T., Petek Sylvain, Debitus Cécile, Al-Mourabit A.
Source
Natural Product Research, 2018,
32 (13), p. 1512-1517 ISSN 1478-6419
Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range. [GRAPHICS] .
