Letellier N., Gutierrez L. A., Carriere I., Gabelle A., Dartigues J. F., Dufouil C., Helmer C., Cadot Emmanuelle, Berr C. (2018). Sex-specific association between neighborhood characteristics and dementia : the Three-City cohort. Alzheimers and Dementia, 14 (4), p. 473-482. ISSN 1552-5260.
Titre du document
Sex-specific association between neighborhood characteristics and dementia : the Three-City cohort
Letellier N., Gutierrez L. A., Carriere I., Gabelle A., Dartigues J. F., Dufouil C., Helmer C., Cadot Emmanuelle, Berr C.
Source
Alzheimers and Dementia, 2018,
14 (4), p. 473-482 ISSN 1552-5260
Introduction: The living environment affects general health and may influence cognitive aging; however, the relationships between neighborhood characteristics and dementia are still poorly understood. Methods: We used data from a French population-based prospective study (the Three-City cohort) that included 7016 participants aged 65 years and older with a 12-year follow-up. We used principal components analysis of neighborhood composition indicators to construct the Three-City deprivation score. To study its impact on dementia incidence, we performed survival analyses using a marginal Cox model to take into account intraneighborhood correlations. As interaction with sex was significant, analyses were stratified by sex. Results: Even after controlling on individual factors, women living in deprived neighborhoods were at higher risk of dementia (hazard ratio = 1.29, 95% confidence interval 1.00-1.67) and Alzheimer's disease (hazard ratio = 1.42, 95% confidence interval 1.09-1.84). No association was found for men. Discussion: Living in a deprived neighborhood is associated with higher risk of dementia in women.
Plan de classement
Sciences du milieu [021]
;
Santé : aspects socioculturels, économiques et politiques [056]
;
Urbanisation et sociétés urbaines [102]
