%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Letellier, N.
%A Gutierrez, L. A.
%A Carriere, I.
%A Gabelle, A.
%A Dartigues, J. F.
%A Dufouil, C.
%A Helmer, C.
%A Cadot, Emmanuelle
%A Berr, C.
%T Sex-specific association between neighborhood characteristics and dementia : the Three-City cohort
%D 2018
%L fdi:010072810
%G ENG
%J Alzheimers and Dementia
%@ 1552-5260
%K Dementia ; Socioeconomic status ; Living environment ; Neighborhood ; Deprivation score ; Gender
%K FRANCE ; BORDEAUX ; DIJON ; MONTPELLIER
%M ISI:000429903200006
%N 4
%P 473-482
%R 10.1016/j.jalz.2017.09.015
%U https://www.documentation.ird.fr/hor/fdi:010072810
%> https://www.documentation.ird.fr/intranet/publi/2018/05/010072810.pdf
%V 14
%W Horizon (IRD)
%X Introduction: The living environment affects general health and may influence cognitive aging; however, the relationships between neighborhood characteristics and dementia are still poorly understood. Methods: We used data from a French population-based prospective study (the Three-City cohort) that included 7016 participants aged 65 years and older with a 12-year follow-up. We used principal components analysis of neighborhood composition indicators to construct the Three-City deprivation score. To study its impact on dementia incidence, we performed survival analyses using a marginal Cox model to take into account intraneighborhood correlations. As interaction with sex was significant, analyses were stratified by sex. Results: Even after controlling on individual factors, women living in deprived neighborhoods were at higher risk of dementia (hazard ratio = 1.29, 95% confidence interval 1.00-1.67) and Alzheimer's disease (hazard ratio = 1.42, 95% confidence interval 1.09-1.84). No association was found for men. Discussion: Living in a deprived neighborhood is associated with higher risk of dementia in women.
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