Stone W. J. R., Campo J. J., Ouedraogo A. L., Meerstein-Kessel L., Morlais Isabelle, Da D., Cohuet Anna, Nsango S., Sutherland C. J., van de Vegte-Bolmer M., Siebelink-Stoter R., van Gemert G. J., Graumans W., Lanke K., Shandling A. D., Pablo J. V., Teng A. A., Jones S., de Jong R. M., Fabra-Garcia A., Bradley J., Roeffen W., Lasonder E., Gremo G., Schwarzer E., Janse C. J., Singh S. K., Theisen M., Felgner P., Marti M., Drakeley C., Sauerwein R., Bousema T., Jore M. M. (2018). Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity. Nature Communications, 9, p. art. 558 [14 p.]. ISSN 2041-1723.
Titre du document
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
Année de publication
2018
Auteurs
Stone W. J. R., Campo J. J., Ouedraogo A. L., Meerstein-Kessel L., Morlais Isabelle, Da D., Cohuet Anna, Nsango S., Sutherland C. J., van de Vegte-Bolmer M., Siebelink-Stoter R., van Gemert G. J., Graumans W., Lanke K., Shandling A. D., Pablo J. V., Teng A. A., Jones S., de Jong R. M., Fabra-Garcia A., Bradley J., Roeffen W., Lasonder E., Gremo G., Schwarzer E., Janse C. J., Singh S. K., Theisen M., Felgner P., Marti M., Drakeley C., Sauerwein R., Bousema T., Jore M. M.
Source
Nature Communications, 2018,
9, p. art. 558 [14 p.] ISSN 2041-1723
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CAMEROUN ; GAMBIE ; BURKINA FASO ; PAYS BAS
Localisation
Fonds IRD [F B010072346]
Identifiant IRD
fdi:010072346
