%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Stone, W. J. R.
%A Campo, J. J.
%A Ouedraogo, A. L.
%A Meerstein-Kessel, L.
%A Morlais, Isabelle
%A Da, D.
%A Cohuet, Anna
%A Nsango, S.
%A Sutherland, C. J.
%A van de Vegte-Bolmer, M.
%A Siebelink-Stoter, R.
%A van Gemert, G. J.
%A Graumans, W.
%A Lanke, K.
%A Shandling, A. D.
%A Pablo, J. V.
%A Teng, A. A.
%A Jones, S.
%A de Jong, R. M.
%A Fabra-Garcia, A.
%A Bradley, J.
%A Roeffen, W.
%A Lasonder, E.
%A Gremo, G.
%A Schwarzer, E.
%A Janse, C. J.
%A Singh, S. K.
%A Theisen, M.
%A Felgner, P.
%A Marti, M.
%A Drakeley, C.
%A Sauerwein, R.
%A Bousema, T.
%A Jore, M. M.
%T Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
%D 2018
%L fdi:010072346
%G ENG
%J Nature Communications
%@ 2041-1723
%K CAMEROUN ; GAMBIE ; BURKINA FASO ; PAYS BAS
%M ISI:000424451300003
%P art. 558 [14 ]
%R 10.1038/s41467-017-02646-2
%U https://www.documentation.ird.fr/hor/fdi:010072346
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-02/010072346.pdf
%V 9
%W Horizon (IRD)
%X Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.
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