@article{fdi:010072346,
  title = {{U}nravelling the immune signature of {P}lasmodium falciparum transmission-reducing immunity},
  author = {{S}tone, {W}. {J}. {R}. and {C}ampo, {J}. {J}. and {O}uedraogo, {A}. {L}. and {M}eerstein-{K}essel, {L}. and {M}orlais, {I}sabelle and {D}a, {D}. and {C}ohuet, {A}nna and {N}sango, {S}. and {S}utherland, {C}. {J}. and van de {V}egte-{B}olmer, {M}. and {S}iebelink-{S}toter, {R}. and van {G}emert, {G}. {J}. and {G}raumans, {W}. and {L}anke, {K}. and {S}handling, {A}. {D}. and {P}ablo, {J}. {V}. and {T}eng, {A}. {A}. and {J}ones, {S}. and de {J}ong, {R}. {M}. and {F}abra-{G}arcia, {A}. and {B}radley, {J}. and {R}oeffen, {W}. and {L}asonder, {E}. and {G}remo, {G}. and {S}chwarzer, {E}. and {J}anse, {C}. {J}. and {S}ingh, {S}. {K}. and {T}heisen, {M}. and {F}elgner, {P}. and {M}arti, {M}. and {D}rakeley, {C}. and {S}auerwein, {R}. and {B}ousema, {T}. and {J}ore, {M}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nfection with {P}lasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. {H}ere, we determine the transmission-reducing activity ({TRA}) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. {T}ransmission inhibition is significantly associated with antibody responses to {P}fs48/45, {P}fs230, and to 43 novel gametocyte proteins assessed by protein microarray. {I}n field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to {P}fs48/45, {P}fs230 or to combinations of the novel {TRA}-associated proteins. {W}e also show that naturally acquired purified antibodies against key transmission-blocking epitopes of {P}fs48/45 and {P}fs230 are mechanistically involved in {TRA}, whereas sera depleted of these antibodies retain high-level, complement-independent {TRA}. {O}ur analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.},
  keywords = {{CAMEROUN} ; {GAMBIE} ; {BURKINA} {FASO} ; {PAYS} {BAS}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {9},
  numero = {},
  pages = {art. 558 [14 p.]},
  ISSN = {2041-1723},
  year = {2018},
  DOI = {10.1038/s41467-017-02646-2},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072346},
}