Mesquita I., Varela P., Belinha A., Gaifem J., Laforge M., Vergnes Baptiste, Estaquier J., Silvestre R. (2016). Exploring NAD(+) metabolism in host-pathogen interactions. Cellular and Molecular Life Sciences, 73 (6), p. 1225-1236. ISSN 1420-682X.
Titre du document
Exploring NAD(+) metabolism in host-pathogen interactions
Mesquita I., Varela P., Belinha A., Gaifem J., Laforge M., Vergnes Baptiste, Estaquier J., Silvestre R.
Source
Cellular and Molecular Life Sciences, 2016,
73 (6), p. 1225-1236 ISSN 1420-682X
Nicotinamide adenine dinucleotide (NAD(+)) is a vital molecule found in all living cells. NAD(+) intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD(+) metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD(+) metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD(+) homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD(+) or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD(+) metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
