%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Mesquita, I.
%A Varela, P.
%A Belinha, A.
%A Gaifem, J.
%A Laforge, M.
%A Vergnes, Baptiste
%A Estaquier, J.
%A Silvestre, R.
%T Exploring NAD(+) metabolism in host-pathogen interactions
%D 2016
%L fdi:010066210
%G ENG
%J Cellular and Molecular Life Sciences
%@ 1420-682X
%K Nicotinamide adenine dinucleotide (NAD(+)) ; Host-pathogen interaction ; NAD(+)/NADH ratio ; NADPH ; Sirtuins ; L-tryptophan
%M ISI:000371079200008
%N 6
%P 1225-1236
%R 10.1007/s00018-015-2119-4
%U https://www.documentation.ird.fr/hor/fdi:010066210
%> https://www.documentation.ird.fr/intranet/publi/2016/03/010066210.pdf
%V 73
%W Horizon (IRD)
%X Nicotinamide adenine dinucleotide (NAD(+)) is a vital molecule found in all living cells. NAD(+) intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD(+) metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD(+) metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD(+) homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD(+) or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD(+) metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.
%$ 020