@article{fdi:010066210,
  title = {{E}xploring {NAD}(+) metabolism in host-pathogen interactions},
  author = {{M}esquita, {I}. and {V}arela, {P}. and {B}elinha, {A}. and {G}aifem, {J}. and {L}aforge, {M}. and {V}ergnes, {B}aptiste and {E}staquier, {J}. and {S}ilvestre, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{N}icotinamide adenine dinucleotide ({NAD}(+)) is a vital molecule found in all living cells. {NAD}(+) intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. {T}he regulation of {NAD}(+) metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. {I}ncreasing interest has been given to {NAD}(+) metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. {W}hile the maintenance of {NAD}(+) homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in {NAD}(+) or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. {H}ere, we review the double-edged sword of {NAD}(+) metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.},
  keywords = {{N}icotinamide adenine dinucleotide ({NAD}(+)) ; {H}ost-pathogen interaction ; {NAD}(+)/{NADH} ratio ; {NADPH} ; {S}irtuins ; {L}-tryptophan},
  booktitle = {},
  journal = {{C}ellular and {M}olecular {L}ife {S}ciences},
  volume = {73},
  numero = {6},
  pages = {1225--1236},
  ISSN = {1420-682{X}},
  year = {2016},
  DOI = {10.1007/s00018-015-2119-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066210},
}