Homkham N., Cressey T. R., Bouazza N., Chanta C., Aurpibul L., Narkbunnam T., Krikajornkitti S., Kamonpakorn N., Lallemant Marc, Ingsrisawang L., Salvadori Nicolas, Treluyer J. M., Urien S., Jourdain Gonzague. (2015). Efavirenz concentrations and probability of HIV replication in children. Pediatric Infectious Disease Journal, 34 (11), p. 1214-1217. ISSN 0891-3668.
Titre du document
Efavirenz concentrations and probability of HIV replication in children
In 188 HIV-infected children receiving efavirenz, a lower mid-dose (C-12) was associated with a higher risk of HIV-1 viral load >400 copies/mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C-12 below target threshold (<1.0mg/L) with a 23% risk of viral replication.