Publications des scientifiques de l'IRD

Homkham N., Cressey T. R., Bouazza N., Chanta C., Aurpibul L., Narkbunnam T., Krikajornkitti S., Kamonpakorn N., Lallemant Marc, Ingsrisawang L., Salvadori Nicolas, Treluyer J. M., Urien S., Jourdain Gonzague. (2015). Efavirenz concentrations and probability of HIV replication in children. Pediatric Infectious Disease Journal, 34 (11), p. 1214-1217. ISSN 0891-3668.

Titre du document
Efavirenz concentrations and probability of HIV replication in children
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000363530500013
Auteurs
Homkham N., Cressey T. R., Bouazza N., Chanta C., Aurpibul L., Narkbunnam T., Krikajornkitti S., Kamonpakorn N., Lallemant Marc, Ingsrisawang L., Salvadori Nicolas, Treluyer J. M., Urien S., Jourdain Gonzague
Source
Pediatric Infectious Disease Journal, 2015, 34 (11), p. 1214-1217 ISSN 0891-3668
In 188 HIV-infected children receiving efavirenz, a lower mid-dose (C-12) was associated with a higher risk of HIV-1 viral load >400 copies/mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C-12 below target threshold (<1.0mg/L) with a 23% risk of viral replication.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
THAILANDE
Localisation
Fonds IRD [F B010065424]
Identifiant IRD
fdi:010065424
Contact