@article{fdi:010065424, title = {{E}favirenz concentrations and probability of {HIV} replication in children}, author = {{H}omkham, {N}. and {C}ressey, {T}. {R}. and {B}ouazza, {N}. and {C}hanta, {C}. and {A}urpibul, {L}. and {N}arkbunnam, {T}. and {K}rikajornkitti, {S}. and {K}amonpakorn, {N}. and {L}allemant, {M}arc and {I}ngsrisawang, {L}. and {S}alvadori, {N}icolas and {T}reluyer, {J}. {M}. and {U}rien, {S}. and {J}ourdain, {G}onzague}, editor = {}, language = {{ENG}}, abstract = {{I}n 188 {HIV}-infected children receiving efavirenz, a lower mid-dose ({C}-12) was associated with a higher risk of {HIV}-1 viral load >400 copies/m{L} ({P} = 0.03). {S}imulations for a normalized population receiving {US} {F}ood and {D}rug {A}dministration weight-band dosing predicted that 15% of children would have a {C}-12 below target threshold (<1.0mg/{L}) with a 23% risk of viral replication.}, keywords = {pharmacokinetics ; {HIV} ; efavirenz ; children ; {THAILANDE}}, booktitle = {}, journal = {{P}ediatric {I}nfectious {D}isease {J}ournal}, volume = {34}, numero = {11}, pages = {1214--1217}, ISSN = {0891-3668}, year = {2015}, DOI = {10.1097/inf.0000000000000854}, URL = {https://www.documentation.ird.fr/hor/fdi:010065424}, }