%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Homkham, N.
%A Cressey, T. R.
%A Bouazza, N.
%A Chanta, C.
%A Aurpibul, L.
%A Narkbunnam, T.
%A Krikajornkitti, S.
%A Kamonpakorn, N.
%A Lallemant, Marc
%A Ingsrisawang, L.
%A Salvadori, Nicolas
%A Treluyer, J. M.
%A Urien, S.
%A Jourdain, Gonzague
%T Efavirenz concentrations and probability of HIV replication in children
%D 2015
%L fdi:010065424
%G ENG
%J Pediatric Infectious Disease Journal
%@ 0891-3668
%K pharmacokinetics ; HIV ; efavirenz ; children
%K THAILANDE
%M ISI:000363530500013
%N 11
%P 1214-1217
%R 10.1097/inf.0000000000000854
%U https://www.documentation.ird.fr/hor/fdi:010065424
%> https://www.documentation.ird.fr/intranet/publi/2015/11/010065424.pdf
%V 34
%W Horizon (IRD)
%X In 188 HIV-infected children receiving efavirenz, a lower mid-dose (C-12) was associated with a higher risk of HIV-1 viral load >400 copies/mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C-12 below target threshold (<1.0mg/L) with a 23% risk of viral replication.
%$ 052 ; 050