Publications des scientifiques de l'IRD

D'Arc M., Ayouba Ahidjo, Esteban Amandine, Learn G. H., Boue V., Liégeois Florian, Etienne L., Tagg N., Leendertz F. H., Boesch C., Madinda N. F., Robbins M. M., Gray M., Cournil Amandine, Ooms M., Letko M., Simon V. A., Sharp P. M., Hahn B. H., Delaporte Eric, Ngole E. M., Peeters Martine. (2015). Origin of the HIV-1 group O epidemic in western lowland gorillas. Proceedings of the National Academy of Sciences of the United States of America, 112 (11), p. E1343-E1352. ISSN 0027-8424.

Titre du document
Origin of the HIV-1 group O epidemic in western lowland gorillas
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000351060000024
Auteurs
D'Arc M., Ayouba Ahidjo, Esteban Amandine, Learn G. H., Boue V., Liégeois Florian, Etienne L., Tagg N., Leendertz F. H., Boesch C., Madinda N. F., Robbins M. M., Gray M., Cournil Amandine, Ooms M., Letko M., Simon V. A., Sharp P. M., Hahn B. H., Delaporte Eric, Ngole E. M., Peeters Martine
Source
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (11), p. E1343-E1352 ISSN 0027-8424
HIV-1, the cause of AIDS, is composed of four phylogenetic lineages, groups M, N, O, and P, each of which resulted from an independent cross-species transmission event of simian immunodeficiency viruses (SIVs) infecting African apes. Although groups M and N have been traced to geographically distinct chimpanzee communities in southern Cameroon, the reservoirs of groups O and P remain unknown. Here, we screened fecal samples fromwestern lowland (n = 2,611), eastern lowland (n = 103), and mountain (n = 218) gorillas for gorilla SIV (SIVgor) antibodies and nucleic acids. Despite testing wild troops throughout southern Cameroon (n = 14), northern Gabon (n = 16), the Democratic Republic of Congo (n = 2), and Uganda (n = 1), SIVgor was identified at only four sites in southern Cameroon, with prevalences ranging from 0.8-22%. Amplification of partial and full-length SIVgor sequences revealed extensive genetic diversity, but all SIVgor strains were derived from a single lineage within the chimpanzee SIV (SIVcpz) radiation. Two fully sequenced gorilla viruses from southwestern Cameroon were very closely related to, and likely represent the source population of, HIV-1 group P. Most of the genome of a third SIVgor strain, from central Cameroon, was very closely related to HIV-1 group O, again pointing to gorillas as the immediate source. Functional analyses identified the cytidine deaminase APOBEC3G as a barrier for chimpanzee-to-gorilla, but not gorilla-to-human, virus transmission. These data indicate that HIV-1 group O, which spreads epidemically in west central Africa and is estimated to have infected around 100,000 people, originated by cross-species transmission from western lowland gorillas.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080]
Description Géographique
CAMEROUN ; GABON ; REPUBLIQUE DEMOCRATIQUE DU CONGO ; OUGANDA
Localisation
Fonds IRD [F B010064059]
Identifiant IRD
fdi:010064059
Contact