Gil A., Pabon A., Galiano S., Burguete A., Perez-Silanes S., Deharo Eric, Monge A., Aldana I. (2014). Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents. Molecules, 19 (2), p. 2166-2180. ISSN 1420-3049.
Titre du document
Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
Gil A., Pabon A., Galiano S., Burguete A., Perez-Silanes S., Deharo Eric, Monge A., Aldana I.
Source
Molecules, 2014,
19 (2), p. 2166-2180 ISSN 1420-3049
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
