@article{fdi:010061992, title = {{S}ynthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-{P}lasmodium falciparum agents}, author = {{G}il, {A}. and {P}abon, {A}. and {G}aliano, {S}. and {B}urguete, {A}. and {P}erez-{S}ilanes, {S}. and {D}eharo, {E}ric and {M}onge, {A}. and {A}ldana, {I}.}, editor = {}, language = {{ENG}}, abstract = {{W}e report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-{N}-oxide derivatives, eight of which are completely novel. {C}ompounds 1a and 2a were the most active against {P}lasmodium falciparum strains. {S}tructure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.}, keywords = {{P}lasmodium falciparum ; antimalarial agents ; quinoxaline ; quinoxaline ; 1,4-di-{N}-oxide chalcone}, booktitle = {}, journal = {{M}olecules}, volume = {19}, numero = {2}, pages = {2166--2180}, ISSN = {1420-3049}, year = {2014}, DOI = {10.3390/molecules19022166}, URL = {https://www.documentation.ird.fr/hor/fdi:010061992}, }