%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Gil, A.
%A Pabon, A.
%A Galiano, S.
%A Burguete, A.
%A Perez-Silanes, S.
%A Deharo, Eric
%A Monge, A.
%A Aldana, I.
%T Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
%D 2014
%L fdi:010061992
%G ENG
%J Molecules
%@ 1420-3049
%K Plasmodium falciparum ; antimalarial agents ; quinoxaline ; quinoxaline ; 1,4-di-N-oxide chalcone
%M ISI:000334418200050
%N 2
%P 2166-2180
%R 10.3390/molecules19022166
%U https://www.documentation.ird.fr/hor/fdi:010061992
%> https://www.documentation.ird.fr/intranet/publi/2014/06/010061992.pdf
%V 19
%W Horizon (IRD)
%X We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
%$ 020 ; 050 ; 052