Madelain V., Oestereich L., Graw F., Nguyen T. H. T., de Lamballerie Xavier, Mentre F., Gunther S., Guedj J. (2015). Ebola virus dynamics in mice treated with favipiravir. Antiviral Research, 123, p. 70-77. ISSN 0166-3542.
Titre du document
Ebola virus dynamics in mice treated with favipiravir
Madelain V., Oestereich L., Graw F., Nguyen T. H. T., de Lamballerie Xavier, Mentre F., Gunther S., Guedj J.
Source
Antiviral Research, 2015,
123, p. 70-77 ISSN 0166-3542
The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8 days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, such as the half-life of productively infected cells, of about 6 h, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. Furthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6 days after initiation of treatment, respectively. The model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
