%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Madelain, V.
%A Oestereich, L.
%A Graw, F.
%A Nguyen, T. H. T.
%A de Lamballerie, Xavier
%A Mentre, F.
%A Gunther, S.
%A Guedj, J.
%T Ebola virus dynamics in mice treated with favipiravir
%D 2015
%L PAR00013945
%G ENG
%J Antiviral Research
%@ 0166-3542
%K Ebola ; Viral kinetics ; Modeling ; Favipiravir
%M ISI:000365368600009
%P 70-77
%R 10.1016/j.antiviral.2015.08.015
%U https://www.documentation.ird.fr/hor/PAR00013945
%V 123
%W Horizon (IRD)
%X The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8 days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, such as the half-life of productively infected cells, of about 6 h, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. Furthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6 days after initiation of treatment, respectively. The model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.
%$ 052 ; 080 ; 050