@article{PAR00013945,
  title = {{E}bola virus dynamics in mice treated with favipiravir},
  author = {{M}adelain, {V}. and {O}estereich, {L}. and {G}raw, {F}. and {N}guyen, {T}. {H}. {T}. and de {L}amballerie, {X}avier and {M}entre, {F}. and {G}unther, {S}. and {G}uedj, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he polymerase inhibitor favipiravir is a candidate for the treatment of {E}bola virus disease. {H}ere, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with {E}bola virus, which were either left untreated or treated with favipiravir at 6 or 8 days post infection. {T}his approach provided estimates of kinetic parameters of {E}bola virus reproduction, such as the half-life of productively infected cells, of about 6 h, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. {F}urthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6 days after initiation of treatment, respectively. {T}he model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.},
  keywords = {{E}bola ; {V}iral kinetics ; {M}odeling ; {F}avipiravir},
  booktitle = {},
  journal = {{A}ntiviral {R}esearch},
  volume = {123},
  numero = {},
  pages = {70--77},
  ISSN = {0166-3542},
  year = {2015},
  DOI = {10.1016/j.antiviral.2015.08.015},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00013945},
}